Prophylactic effect of . seed extract on inflammatory markers and histopathological changes in high-fat-fed ovariectomized rats.

Journal: Journal of traditional and complementary medicine
Published Date: Jul 18, 2021

Abstract

BACKGROUND AND AIM: L. seeds (TFG) are used as spices in Indian cuisine. In Indian traditional medicine, TFG is used to treat diabetes, dyslipidemia, obesity, arthritis, cancer, digestive disorders, and postmenopausal conditions. Pathophysiology of postmenopausal diseases involves low-grade systemic inflammation. The purpose of this study is to investigate the prophylactic effect of petroleum ether fraction of TFG-extract (PE-TFG) on inflammatory markers, and histopathological changes in ovariectomized rats (OVX-rats) fed with a high-fat diet (HFD).

Authors

  • Takkella Nagamma
    Department of Biochemistry, Melaka Manipal Medical College (Manipal Campus), Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
  • Anjaneyulu Konuri
    Department of Anatomy, Manipal-TATA Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
  • Kumar Mr Bhat
    Department of Anatomy, Ras Al Khaimah College of Medical Sciences, RAK Medical & Health Science University, Ras Al Khaimah, United Arab Emirates.
  • Padmanabha Udupa
    Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
  • Guruprasad Rao
    Department of Biochemistry, Melaka Manipal Medical College (Manipal Campus), Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
  • Yogendra Nayak
    Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy, of Higher Education, Manipal, Karnataka, 576104, India.

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