Time-updated anion gap and cardiovascular events in advanced chronic kidney disease: a cohort study.

Journal: Clinical kidney journal
Published Date: Dec 16, 2021

Abstract

BACKGROUND: Studies examining associations between metabolic acidosis and cardiovascular events in chronic kidney disease (CKD) have shown conflicting results and have not differentiated between normal anion gap (hyperchloremic) acidosis and high anion gap acidosis. We aimed to examine the impact of normal and high anion gap acidosis, separately, on the risk of cardiovascular events among patients with CKD.

Authors

  • Yuta Asahina
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan.
  • Yusuke Sakaguchi
    Department of Inter-Organ Communication Research in Kidney Diseases, Osaka University Graduate School of Medicine, Suita, Japan.
  • Sachio Kajimoto
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan.
  • Koki Hattori
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan.
  • Yohei Doi
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan.
  • Tatsufumi Oka
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan.
  • Jun-Ya Kaimori
    Department of Inter-Organ Communication Research in Kidney Diseases, Osaka University Graduate School of Medicine, Suita, Japan.
  • Yoshitaka Isaka
    Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Japan.

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