Chlorinated metabolites with antibacterial activities from a deep-sea-derived fungus.

Journal: RSC advances
Published Date: Sep 3, 2021

Abstract

Chromatographic separation of the solid cultures of a deep-sea-derived fungus (MCCC 3A00308) resulted in the isolation of eight compounds. Their structures were identified on the basis of the spectroscopic data. Compounds 1-8 are classified as depsidone-type (1-4), isocoumarin-type (5 and 6), and benzothiazole-type (7 and 8), of which 1-7 are new compounds and 1-3 along with 5 and 6 are chlorinated. Compound 3 is characterized by trichlorination and shows potent activities against Gram-positive pathogenic bacteria including ATCC 25923, ATCC 10792, and CMCC 63501, with minimum inhibitory concentration (MIC) values ranging from 0.5 to 1.0 μg mL. This study extends the chemical diversity of chlorinated natural products from marine-derived fungi and provides a promising lead for the development of antibacterial agents.

Authors

  • Siwen Niu
    State Key Laboratory of Natural and Biomimetic Drugs, Peking University Beijing 100191 P. R. China whlin@bjmu.edu.cn.
  • Dong Liu
    Department of Gastrointestinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
  • Zongze Shao
    Third Institute of Oceanography, SOA Xiamen 361005 P. R. China.
  • Jiang Huang
    State Key Laboratory of Natural and Biomimetic Drugs, Peking University Beijing 100191 P. R. China whlin@bjmu.edu.cn.
  • Aili Fan
    State Key Laboratory of Natural and Biomimetic Drugs, Peking University Beijing 100191 P. R. China whlin@bjmu.edu.cn.
  • Wenhan Lin
    State Key Laboratory of Natural and Biomimetic Drugs, Peking University Beijing 100191 P. R. China whlin@bjmu.edu.cn.

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