Silver Nanoparticles as an Effective Antimicrobial against Otitis Media Pathogens.

Journal: AIChE journal. American Institute of Chemical Engineers
Published Date: Sep 24, 2021

Abstract

Otitis Media (OM) is the most common reason for U.S. children to receive prescribed oral antibiotics, leading to potential to cause antibiotic resistance. To minimize oral antibiotic usage, we developed polyvinylpyrrolidone-coated silver nanoparticles (AgNPs-PVP), which completely eradicated common OM pathogens, i.e., and non-typeable (NTHi) at 1.04μg/mL and 2.13μg/mL. The greater antimicrobial efficacy against was a result of the HO-producing ability of and the known synergistic interactions between HO and AgNPs. To enable the sustained local delivery of AgNPs-PVP (e.g., via injection through perforated tympanic membranes), a hydrogel formulation of 18%(w/v)P407 was developed. Reverse thermal gelation of the AgNPs-PVP-P407 hydrogel could gel rapidly upon entering the warm auditory bullae and thereby sustained release of antimicrobials. This hydrogel-based local delivery system completely eradicated OM pathogens in vitro without cytotoxicity, and thus represents a promising strategy for treating bacterial OM without relying on conventional antibiotics.

Authors

  • Xiaojing Ma
    Robert F. Smith School of Chemical & Biomolecular Engineering, Cornell University, Ithaca, NY 14850, USA.
  • Jiayan Lang
    Robert F. Smith School of Chemical & Biomolecular Engineering, Cornell University, Ithaca, NY 14850, USA.
  • Pengyu Chen
    Robert F. Smith School of Chemical & Biomolecular Engineering, Cornell University, Ithaca, NY 14850, USA.
  • Rong Yang
    Robert F. Smith School of Chemical & Biomolecular Engineering, Cornell University, Ithaca, NY 14850, USA.

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