Evaluation of the Antidiabetic Potential of an Isolated Hydroalcoholic Fraction from the Fruit of .

Journal: Journal of pharmacy & bioallied sciences
Published Date: Mar 4, 2022

Abstract

The hydro-alcoholic extract of fruits was investigated for preliminary phytochemical screening and characterized by high-performance thin-layer chromatography. Column chromatography of the hydro-alcoholic extract of eluted with four different combinations of ethyl acetate and methanol yielded four fractions (WCF, WCF, WCF and WCF). One of these fractions, WCF, significantly ( < 0.05) inhibited α-amylase and α-glucosidase activity with IC values of 104.71 μg/mL and 70.79 μg/mL, respectively. WCF further reduced blood glucose levels in comparison to control in the starch tolerance test. The extract showed a relative dose-dependent effect. It was observed that none of the extracts could delay the peak blood glucose that was achieved after 60 min of carbohydrate challenge, but these blunted the glycemic peak.

Authors

  • Md Waris
    Department of Botany, Thakur Prasad Singh (TPS) College, Patna, Magadh University, Bodh Gaya, Bihar, India.
  • Naiyer Shahzad
    Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
  • Saeed Saeed Al-Ghamdi
    Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
  • Showkat Rasool Mir
    Department of Pharmacognosy and Phytochemistry, Phytopharmaceutical Research Laboratory, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
  • Tanuja
    Department of Botany, Thakur Prasad Singh (TPS) College, Patna, Magadh University, Bodh Gaya, Bihar, India.

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