Native BK virus nephropathy in lung transplant: a case report and literature review.

Journal: Clinical kidney journal
Published Date: Dec 10, 2021

Abstract

Classically described in renal allografts, BK virus nephropathy is increasingly recognized in native kidneys of other non-renal solid organ transplants. We discuss a 68-year-old woman with a history of bilateral lung transplant referred for worsening renal function, confirmed to have BK virus nephropathy by biopsy with a serum BK virus polymerase chain reaction of over 59 million copies/mL. She was managed with a reduction in immunosuppression and intravenous cidofovir with no improvement in her clinical parameters. The seven prior reported cases of polyoma virus nephropathy in lung transplant recipients are reviewed, and the challenges of screening and management are discussed.

Authors

  • Waseem Albasha
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Arizona College of Medicine, Tucson, AZ, USA.
  • Golnaz Vahdani
    Division of Nephrology, Department of Medicine, University of Arizona College of Medicine, Tucson, AZ, USA.
  • Ankita Ashoka
    Department of Medicine, University of Arizona College of Medicine, Tucson, AZ, USA.
  • Erika Bracamonte
    Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA.
  • Amy A Yau
    Division of Nephrology, Department of Medicine, The Ohio State University, Columbus, OH, USA.

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