Leveraging the potential of machine learning for assessing vascular ageing: state-of-the-art and future research.

Journal: European heart journal. Digital health
Published Date:

Abstract

Vascular ageing biomarkers have been found to be predictive of cardiovascular risk independently of classical risk factors, yet are not widely used in clinical practice. In this review, we present two basic approaches for using machine learning (ML) to assess vascular age: parameter estimation and risk classification. We then summarize their role in developing new techniques to assess vascular ageing quickly and accurately. We discuss the methods used to validate ML-based markers, the evidence for their clinical utility, and key directions for future research. The review is complemented by case studies of the use of ML in vascular age assessment which can be replicated using freely available data and code.

Authors

  • Vasiliki Bikia
    Laboratory of Hemodynamics and Cardiovascular Technology (LHTC), Swiss Federal Institute of Technology, CH-1015 Lausanne, Vaud, Switzerland.
  • Terence Fong
    Baker Heart and Diabetes Institute, 75 Commercial Rd, Melbourne, Victoria, 3004 Australia.
  • Rachel E Climie
    Baker Heart and Diabetes Institute, 75 Commercial Rd, Melbourne, Victoria, 3004 Australia.
  • Rosa-Maria Bruno
    Universite' de Paris, INSERM U970, Paris Cardiovascular Research Centre, Integrative Epidemiology of Cardiovascular Disease, Paris, France.
  • Bernhard Hametner
    Center for Health & Bioresources, AIT Austrian Institute of Technology, Giefinggasse 4, 1210 Vienna, Austria.
  • Christopher Mayer
    Center for Health & Bioresources, AIT Austrian Institute of Technology, Giefinggasse 4, 1210 Vienna, Austria.
  • Dimitrios Terentes-Printzios
    First Department of Cardiology, Hippokration Hospital, Medical School, National and Kapodistrian University of Athens, 114 Vasilissis Sofias Avenue, 11527, Athens, Greece.
  • Peter H Charlton
    Department of Public Health and Primary Care, Strangeways Research Laboratory, 2 Worts' Causeway, Cambridge, CB1 8RN, UK.

Keywords

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