Skeletal muscle myostatin gene expression and sarcopenia in overweight and obese middle-aged and older adults.

Journal: JCSM clinical reports
Published Date: Sep 23, 2021

Abstract

BACKGROUND: Myostatin (MSTN) is a key negative regulator of muscle mass in humans and animals, having direct and indirect influences on molecular regulators of atrophy and hypertrophy, thus potentially impacting fitness and physical function. We have shown that myostatin is elevated in conditions of chronic disability (e.g. paretic limb of stroke). Our hypothesis is that myostatin would be elevated in older adults with sarcopenia. The purpose of this study was to examine the role of skeletal muscle myostatin in sarcopenia.

Authors

  • Alice S Ryan
    Department of Medicine, University of Maryland, Baltimore, Maryland, USA.
  • Guoyan Li
    Department of Veterans Affairs, Department of Medicine, Division of Gerontology and Palliative Medicine, and the Baltimore VA Medical Center Geriatrics, Research, Education Center (GRECC), VA Maryland Health Care System, Baltimore, MD 21201, USA.

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