Engineering naphthalimide-cyanine integrated near-infrared dye into ROS-responsive nanohybrids for tumor PDT/PTT/chemotherapy.

Journal: Bioactive materials
Published Date: Dec 20, 2021

Abstract

Photodynamic (PDT) and photothermal therapies (PTT) are emerging treatments for tumour ablation. Organic dyes such as porphyrin, chlorin, phthalocyanine, boron-dipyrromethene and cyanine are the clinically or preclinically used photosensitizer or photothermal agents. Development of structurally diverse near-infrared dyes with long absorption wavelength is of great significance for PDT and PTT. Herein, we report a novel near-infrared dye with naphthalimide modified cyanine skeleton. The introduction of naphthalimide moiety results in stronger electron delocalization and larger redshift in emission compared with . Furthermore, is co-loaded with chemotherapeutic drug into ROS-responsive mesoporous organosilica () to construct nanomedicine , which exhibits remarkable tumor inhibition effects through PDT/PTT/chemotherapy in vivo.

Authors

  • Tongxia Jin
    State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, PR China.
  • Di Cheng
    State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, PR China.
  • Guanyu Jiang
    State Key Laboratory of Precision Spectroscopy, School of Physics and Electronic Science, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, PR China.
  • Wenqian Xing
    State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, PR China.
  • Peiwen Liu
    State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, PR China.
  • Bin Wang
    State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Northwest A&F University, Yangling 712100, China; New South Wales Department of Primary Industries, Wagga Wagga Agricultural Institute, Wagga Wagga 2650, Australia. Electronic address: bin.a.wang@dpi.nsw.gov.au.
  • Weiping Zhu
    State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, PR China.
  • Haitao Sun
    State Key Laboratory of Precision Spectroscopy, School of Physics and Electronic Science, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, PR China.
  • Zhenrong Sun
    State Key Laboratory of Precision Spectroscopy, School of Physics and Electronic Science, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, PR China.
  • Yufang Xu
    College of Grassland Science, Qingdao Agricultural University, Qingdao, China.
  • Xuhong Qian
    State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, PR China.

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