In vitro nematocidal activity of L. against gastrointestinal helminths in goats.
Journal:
Journal of parasitic diseases : official organ of the Indian Society for Parasitology
Published Date:
Aug 22, 2021
Abstract
The objective of this study was to evaluate the in vitro ovicidal activity, phytochemistry, and toxicity of a saline extract obtained from peel of L fruits. The ovicidal activity was evaluated by the hatching inhibition of eggs recovered from fecal samples of naturally infected goats; the phytochemical analysis was carried out using the fruit peel; and the toxicity was tested on , using saline extract. The results showed that the ovicidal effect of the tested extract was 99% (25 mg mL), 99% (12.5 mg mL), 98% (6.25 mg mL), and 95% (3.12 mg mL), higher than that of the control drug, thiabendazole (83%). The phytochemical analysis showed presence of phenols, anthraquinones, and condensed and hydrolysable tannins in the fruit extract. The toxicity test of the extract of showed an LC50 of 6.19 mg mL, which indicates a safe use for a concentration of 3.12 mg mL, since it was the tested concentration that was below the reliable LC50. The saline extract from peels of has ovicidal activity, important secondary metabolites, and absence of toxicity at the lowest concentration tested. However, in vivo tests in experimental models are recommended before performing experiments in ruminants.
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