MTT assay based inhibition analysis of A2780 cells proliferation using Lam. extract with CXCR4 and HER2 expression.

Journal: Bioinformation
Published Date: Jul 31, 2021

Abstract

It is of interest to document the inhibition of A2780 cell proliferation using Lam.() extract by MTT assay and by monitoring the CXCR4 and HER2 expression through RT-PCR analysis. Results shown that the n-hexane extract of have anticancer activity IC values of 32.46±0.92 µg/mL on A2780 cell lines. It is further found that the CXCR4 and HER2 mRNA and protein expression were significantly reduced in treated A2780 cell lines. Thus, the n-hexane extract of is a natural source of bioactive compounds as potential anticancer agents.

Authors

  • Chella Perumal Palanisamy
    State Key Laboratory of Biobased Material and Green Papermaking, School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Science, Jinan 250353, China.
  • Shazia Fathima Jh
    Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospitals, Chennai, India.
  • Ramya Sekar
    Department of Oral Pathology, Meenakshi Ammal Dental College, Chennai-600 095, India.
  • Ponnulakshmi Rajagopal
    Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai-600 078, India.
  • Selvaraj Jeyaraman
    Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, India.

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