Potential Surrogate Outcomes for Kidney Failure in Advanced CKD: Evaluation of Power and Predictive Ability in CKDopps.

Journal: Kidney medicine
Published Date: Dec 11, 2021

Abstract

RATIONALE & OBJECTIVE: Potential surrogate end points for kidney failure have been proposed in chronic kidney disease (CKD); however, they must be evaluated to ensure accurate, powerful, and harmonized research, particularly among patients with advanced CKD. The aim of the current study was to investigate the power and predictive ability of surrogate kidney failure end points in a population with moderate-to-advanced CKD.

Authors

  • Jarcy Zee
    Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Daniel Muenz
    Arbor Research Collaborative for Health, Ann Arbor, Michigan.
  • Keith P McCullough
    Arbor Research Collaborative for Health, Ann Arbor, Michigan.
  • Brian Bieber
    Arbor Research Collaborative for Health, Ann Arbor, Michigan.
  • Marie Metzger
    French Institute of Health and Medical Research (INSERM), Villejuif, France.
  • Natalia Alencar de Pinho
    French Institute of Health and Medical Research (INSERM), Villejuif, France.
  • Antonio A Lopes
    Department of Internal Medicine, Federal University of Bahia, Salvador, Brazil.
  • Danilo Fliser
    Universitatsklinikum des Saarlandes und Medizinische Fakultat der Universitat des Saarlandes, Homburg, Saarland, Germany.
  • Bruce M Robinson
    Arbor Research Collaborative for Health, Ann Arbor, Michigan.
  • Eric Young
    Arbor Research Collaborative for Health, Ann Arbor, Michigan.
  • Ronald L Pisoni
    Arbor Research Collaborative for Health, Ann Arbor, Michigan.
  • Bénédicte Stengel
    French Institute of Health and Medical Research (INSERM), Villejuif, France.
  • Roberto Pecoits-Filho
    Arbor Research Collaborative for Health, Ann Arbor, Michigan.

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