Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Versus Dolutegravir/Abacavir/Lamivudine in Antiretroviral-Naive Adults (SYMTRI): A Multicenter Randomized Open-Label Study (PReEC/RIS-57).

Journal: Open forum infectious diseases
Published Date: Nov 25, 2021

Abstract

BACKGROUND: Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) is the reference for combination therapy based on protease inhibitors due to its efficacy, tolerability, and convenience. Head-to-head randomized comparisons between D/C/F/TAF and combination therapy based on integrase inhibitors in antiretroviral-naive patients are lacking.

Authors

  • D Podzamczer
    Hospital Universitari de Bellvitge, Barcelona, Spain.
  • R Micán
    Hospital La Paz, Madrid, Spain.
  • J Tiraboschi
    Hospital Universitari de Bellvitge, Barcelona, Spain.
  • J Portilla
    Hospital General Universitario de Alicante, Alicante, Spain.
  • P Domingo
    Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
  • J M Llibre
    Hospital Germans Trias i Pujol, Barcelona, Spain.
  • E Ribera
    Hospital Universitario de la Vall d'Hebrón, Barcelona, Spain.
  • M J Vivancos
    Hospital Universitario Ramón y Cajal, Madrid, Universidad de Alcalá, IRYCIS, Madrid, Spain.
  • L Morano
    Hospital Universitario Álvaro Cunqueiro, Vigo, Spain.
  • M Masiá
    Hospital General Universitario de Elche, Elche, Spain.
  • C Gómez
    Hospital Universitario Virgen de la Victoria-IBIMA, Málaga, Spain.
  • F Fanjul
    Hospital Universitario Son Espases, Palma, Spain.
  • A Payeras
    Hospital Universitario Son Llàtzer, Palma, Spain.
  • A Inciarte
    Hospital Clínic, Barcelona, Spain.
  • V Estrada
    Hospital Clínico San Carlos-IdiSSC, Madrid, Spain.
  • A Rivero
    Hospital Universitario Reina Sofía, Córdoba, Spain.
  • Á Castro
    Complejo Hospitalario Universitario, A Coruña, Spain.
  • E Bernal
    Hospital Universitario Reina Sofía, Murcia, Spain.
  • D Vinuesa
    Hospital Universitario Clínico San Cecilio, Granada, Spain.
  • H Knobel
    Hospital del Mar, Barcelona, Spain.
  • J Troya
    Hospital Universitario Infanta Leonor, Madrid, Spain.
  • J Macías
    Hospital Universitario Virgen de Valme, Sevilla, Spain.
  • M Montero
    Hospital Universitari i Politècnic La Fe, Valencia, Spain.
  • J Sanz
    Hospital Universitario de La Princesa, Madrid, Spain.
  • A Navarro-Alcaraz
    Hospital Universitari de Bellvitge, Barcelona, Spain.
  • A Caicedo
    RIS Red de Investigación en SIDA, Madrid, Spain.
  • G Fernández
    Hospital Universitari de Bellvitge, Barcelona, Spain.
  • E Martínez
    Hospital Clínic, Barcelona, Spain.
  • S Moreno
    Hospital Universitario Ramón y Cajal, Madrid, Universidad de Alcalá, IRYCIS, Madrid, Spain.

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