Iron Deficiency Impacts Diastolic Function, Aerobic Exercise Capacity, and Patient Phenotyping in Heart Failure With Preserved Ejection Fraction: A Subanalysis of the OptimEx-Clin Study.

Journal: Frontiers in physiology
Published Date: Feb 10, 2022

Abstract

AIMS: Iron deficiency (ID) is linked to reduced aerobic exercise capacity and poor prognosis in patients with heart failure (HF) with reduced ejection fraction (HFrEF); however, data for HF with preserved ejection fraction (HFpEF) is scarce. We assessed the relationship between iron status and diastolic dysfunction as well as aerobic exercise capacity in HFpEF, and the contribution of iron status to patient phenotyping.

Authors

  • Andreas B Gevaert
    Research Group Cardiovascular Diseases, GENCOR Department, University of Antwerp, Antwerp, Belgium.
  • Stephan Mueller
    Department of Prevention and Sports Medicine, University Hospital Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
  • Ephraim B Winzer
    Department of Internal Medicine and Cardiology, Heart Center Dresden - University Hospital, Technische Universität Dresden, Dresden, Germany.
  • André Duvinage
    Department of Prevention and Sports Medicine, University Hospital Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
  • Caroline M Van De Heyning
    Research Group Cardiovascular Diseases, GENCOR Department, University of Antwerp, Antwerp, Belgium.
  • Elisabeth Pieske-Kraigher
    Department of Internal Medicine and Cardiology, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Paul J Beckers
    Department of Cardiology, Antwerp University Hospital (UZA), Edegem, Belgium.
  • Frank Edelmann
    Department of Internal Medicine and Cardiology, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Ulrik Wisløff
    Cardiac Exercise Research Group at Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
  • Burkert Pieske
    Department of Internal Medicine and Cardiology, Campus Virchow Klinikum, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Volker Adams
    Department of Internal Medicine and Cardiology, Heart Center Dresden - University Hospital, Technische Universität Dresden, Dresden, Germany.
  • Martin Halle
    Department of Prevention and Sports Medicine, University Hospital Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
  • Emeline M Van Craenenbroeck
    Research Group Cardiovascular Diseases, GENCOR (Genetics, Pharmacology & Physiopathology of Heart, Blood, Vessels and Skeleton) Department, University of Antwerp, Antwerp, Belgium.

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