Stability of Ampicillin in Normal Saline Following Refrigerated Storage and 24-Hour Pump Recirculation.
Journal:
Hospital pharmacy
Published Date:
May 31, 2020
Abstract
OBJECTIVE: Use of ampicillin in outpatient parenteral antimicrobial therapy (OPAT) has historically been complicated by frequent dosing and limited stability. The purpose of this study was to evaluate stability of ampicillin using high-pressure liquid chromatography (HPLC) in an OPAT dosing model using continuous infusion at room temperature over 24 hours immediately following preparation compared with batches stored under refrigeration for 24 hours, 72 hours, and 7 days.
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