Fetal bladder rupture after high-dose maternal opioid treatment: a case report.

Journal: Case reports in perinatal medicine
Published Date: Apr 29, 2024

Abstract

OBJECTIVES: Fetal bladder rupture is rare and mainly caused by lower urinary tract obstruction (LUTO). Our case report describes a rupture at a gestational age of 31 weeks following high-dose maternal opioid exposure during intensive care treatment. Opioids perturb the interplay of afferent and efferent signals between the bladder, urethra, and the central nervous system (CNS) which is crucial in contributing to urinary retention. They rapidly cross the human placenta, affecting also the fetus. To date, there is no clear proof of the connection between maternal opioid treatment and fetal bladder rupture, but the association seems to strengthen.

Authors

  • Julia Herken
    Department of Obstetrics and Gynecology, Lucerne Cantonal Hospital, Luzern, Switzerland.
  • Vincent Uerlings
    Department of Obstetrics and Gynecology, Lucerne Cantonal Hospital, Luzern, Switzerland.
  • Sabine Zundel
    Department of Pediatric Surgery, Children's Hospital Lucerne, Luzern, Switzerland.
  • Jonathan Aichner
    Department of Pediatric Surgery, Children's Hospital Lucerne, Luzern, Switzerland.
  • Markus Hodel
    Department of Obstetrics and Gynecology, Lucerne Cantonal Hospital, Luzern, Switzerland.

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