The Role of Proinflammatory Outer Membrane Protein and Propolis in Immunomodulation on U937 Macrophage Cell Model.

Journal: Galen medical journal
Published Date: Dec 8, 2020

Abstract

BACKGROUND: Regarding the important role of proinflammatory outer membrane protein (OipA) in the pathogenesis of infection and immunomodulatory activity of propolis, we aimed to evaluate the immunogenicity effect of a purified recombinant OipA protein and propolis in the induction of two cytokines, interferon-gamma (IFN-γ) and interleukin-4 (IL-4), in a macrophage cell model.

Authors

  • Hengameh Soudi
    Microbiology Department, Faculty of Biological Sciences, Alzahra University, Tehran, Iran.
  • Tahereh Falsafi
    Microbiology Department, Faculty of Biological Sciences, Alzahra University, Tehran, Iran.
  • Sara Gharavi
    Biotechnology Department, Faculty of Biological Sciences, Alzahra University, Tehran, Iran.
  • Mohaddeseh Mahboubi
    Medicinal Plants Research Department, Research and Development, Tabib-Daru Pharmaceutical Company, Kashan, Iran.

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