Investigation of the Dose-Enhancement Effects of Spherical and Rod-Shaped Gold Nanoparticles on the HeLa Cell Line.

Journal: Galen medical journal
Published Date: Aug 4, 2020

Abstract

BACKGROUND: Cervical cancer cells are known as radioresistant cells. Current treatment methods have not improved the patients' survival efficiently; thus, new therapeutic strategies are needed to enhance the efficacy of radiotherapy. Gold nanomaterials with different shapes and sizes have been explored as radiosensitizers. The present study compared the radiosensitizing effects of gold nanorods (AuNRs) with spherical gold nanoparticles (AuNPs) on the HeLa cell line irradiated with megavoltage X-rays.

Authors

  • Samad Amani
    Shiraz University of Medical Sciences, Shiraz, Iran.
  • Alireza Mehdizadeh
    Department of Medical Physics and Medical Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Mohammad Mehdi Movahedi
    Department of Medical Physics and Medical Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Marzieh Keshavarz
    Department of Medical Physics and Medical Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Fereshteh Koosha
    Department of Radiology Technology, Faculty of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Keywords

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