Machine Learning Identifies Clinical and Genetic Factors Associated With Anthracycline Cardiotoxicity in Pediatric Cancer Survivors.

Journal: JACC. CardioOncology
Published Date:

Abstract

BACKGROUND: Despite known clinical risk factors, predicting anthracycline cardiotoxicity remains challenging.

Authors

  • Marie-A Chaix
    Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Neha Parmar
    Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Caroline Kinnear
    Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Myriam Lafreniere-Roula
    Ted Rogers Computational Medicine Program, University Health Network, Toronto, Ontario, Canada.
  • Oyediran Akinrinade
    Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Roderick Yao
    Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Anastasia Miron
    Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Emily Lam
    Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Guoliang Meng
    Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Anne Christie
    Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Ashok Kumar Manickaraj
    Department of Molecular Genetics, University of Toronto, Ontario, Canada.
  • Stacey Marjerrison
    Department of Pediatrics, McMaster University Children's Hospital, Hamilton, Ontario, Canada.
  • Rejane Dillenburg
    Department of Pediatrics, McMaster University Children's Hospital, Hamilton, Ontario, Canada.
  • Mylène Bassal
    Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.
  • Jane Lougheed
    Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.
  • Shayna Zelcer
    Department of Pediatrics, Children's Hospital, London Health Sciences Centre, London, Ontario, Canada.
  • Herschel Rosenberg
    Department of Pediatrics, Children's Hospital, London Health Sciences Centre, London, Ontario, Canada.
  • David Hodgson
    Radiation Medicine Program, Princess Margaret Cancer Centre, Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
  • Leonard Sender
    Department of Pediatrics, Children's Hospital of Orange County, Orange, California, USA.
  • Paul Kantor
    Department of Pediatrics, Children's Hospital of Los Angeles, Los Angeles, California, USA.
  • Cedric Manlhiot
    Department of Pediatrics, Johns Hopkins Medical Center, Baltimore, Maryland, USA.
  • James Ellis
    Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • Luc Mertens
    Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
  • Paul C Nathan
    Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
  • Seema Mital
    Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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