F-FDG PET-guided diffusion tractography reveals white matter abnormalities around the epileptic focus in medically refractory epilepsy: implications for epilepsy surgical evaluation.

Journal: European journal of hybrid imaging
Published Date: Jun 25, 2020

Abstract

BACKGROUND: Hybrid PET/MRI can non-invasively improve localization and delineation of the epileptic focus (EF) prior to surgical resection in medically refractory epilepsy (MRE), especially when MRI is negative or equivocal. In this study, we developed a PET-guided diffusion tractography (PET/DTI) approach combining F-fluorodeoxyglucose PET (FDG-PET) and diffusion MRI to investigate white matter (WM) integrity in MRI-negative MRE patients and its potential impact on epilepsy surgical planning.

Authors

  • Stefan E Poirier
    Lawson Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, Ontario, N6A 4 V2, Canada. spoirie6@uwo.ca.
  • Benjamin Y M Kwan
    Department of Diagnostic Radiology, Queen's University, Kingston, Ontario, Canada.
  • Michael T Jurkiewicz
    Department of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
  • Lina Samargandy
    Department of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
  • David A Steven
    Epilepsy Program, Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
  • Ana Suller-Marti
    Epilepsy Program, Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
  • Victor Lam Shin Cheung
    Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
  • Ali R Khan
    Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
  • Jonathan Romsa
    Department of Medical Imaging, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
  • Frank S Prato
    Lawson Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, Ontario, N6A 4 V2, Canada.
  • Jorge G Burneo
    Epilepsy Program, Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
  • Jonathan D Thiessen
    Lawson Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, Ontario, N6A 4 V2, Canada.
  • Udunna C Anazodo
    Lawson Imaging, Lawson Health Research Institute, 268 Grosvenor St., London, Ontario, N6A 4 V2, Canada. uanazodo@lawsonimaging.ca.

Keywords

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