Observational Cross-Sectional Study of Inflammatory Markers After Transient Ischemic Attacks, Acute Coronary Syndromes, and Vascular Stroke Events.

Journal: CJC open
Published Date: Dec 31, 2020

Abstract

We identified the prevalence of elevated high-sensitivity C-reactive protein and interleukin-6 in patients with recent cardiovascular (CV) events with or without prediabetes/diabetes, and in a control group of patients with remote CV events. Interleukin-6 was elevated in patients with prediabetes/diabetes and recent CV events (median, 4.84 pg/mL; interquartile range, 3.27-7.45) compared with patients with remote events (2.36 pg/mL; interquartile range, 1.09-4.00). There was a trend for elevated high-sensitivity C-reactive protein in patients with acute events and prediabetes/diabetes ( = 0.147). This supports the notion that patients with prediabetes/diabetes and recent CV events have higher inflammatory burdens than patients without recent CV events or dysglycemia.

Authors

  • Kevin E Boczar
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  • Peter Liu
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  • Aun Yeong Chong
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  • Derek So
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  • Dar Dowlatshahi
    Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.
  • Katey Rayner
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
  • Rob Beanlands
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

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