Mesenchymal stem cell conditioned medium ameliorates diabetic serum-induced insulin resistance in 3T3-L1 cells.

Journal: Chronic diseases and translational medicine
Published Date: Oct 22, 2020

Abstract

BACKGROUND: Pharmacological factors used to induce insulin resistance (IR) in models may not mimic the full features of type 2 diabetes mellitus (T2DM). This study aimed to examine the ability of diabetic serum (DS) to induce IR and investigate whether adipose-derived mesenchymal stem cell conditioned medium (ADMSC-CM) reverses DS-induced IR.

Authors

  • Avinash Sanap
    Interdisciplinary School of Health Sciences, Savitribai Phule Pune University, Pune 411007, India.
  • Ramesh Bhonde
    Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune 411018, India.
  • Kalpana Joshi
    Department of Biotechnology, Sinhgad College of Engineering affiliated to Savitribai Phule Pune University, Pune 411041, India.

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