Functional Testing for Tranexamic Acid Duration of Action Using Modified Viscoelastometry.

Journal: Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie
Published Date: Nov 9, 2020

Abstract

INTRODUCTION: Tranexamic acid (TXA) is the standard medication to prevent or treat hyperfibrinolysis. However, prolonged inhibition of lysis (so-called "fibrinolytic shutdown") correlates with increased mortality. A new viscoelastometric test enables bedside quantification of the antifibrinolytic activity of TXA using tissue plasminogen activator (TPA).

Authors

  • Tobias Kammerer
    Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.
  • Philipp Groene
    Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.
  • Sophia R Sappel
    Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.
  • Sven Peterss
    Department of Cardiac Surgery, University Hospital, LMU Munich, Munich, Germany.
  • Paula A Sa
    Department of Anesthesiology, Intensive Care and Emergency, Centro Hospitalar Universitario de Porto, Porto, Portugal.
  • Thomas Saller
    Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.
  • Andreas Giebl
    Department of Transfusion Medicine and Hemostaseology, University Hospital Augsburg, Augsburg, Germany.
  • Patrick Scheiermann
    Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.
  • Christian Hagl
    Department of Cardiac Surgery, University Hospital, LMU Munich, Munich, Germany.
  • Simon Thomas Schäfer
    Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.

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