Preparation and characterization of ethylcellulose microspheres for sustained-release of pregabalin.

Journal: Research in pharmaceutical sciences
Published Date: Dec 30, 2020

Abstract

BACKGROUND AND PURPOSE: Pregabalin is used in the treatment of epilepsy, chronic pain, and other psychological disorders. Preparation of pregabalin in the sustained-release formulation will enhance patient compliance and reduce the incidence of side effects. The aim of this study was to prepare sustained-release microspheres for pregabalin utilizing ethylcellulose and evaluate the processing factors that influence the fabrication and the performance of the prepared microspheres.

Authors

  • Haya Yasin
    Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
  • Bashar Al-Taani
    Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
  • Mutaz Sheikh Salem
    Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Keywords

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