Anti-cholinesterase and Neuroprotective Activities of Sweet and Bitter Apricot Kernels ( L.).

Journal: Iranian journal of pharmaceutical research : IJPR
Published Date: Jan 1, 2020

Abstract

Apricot ( L.) is a fruit cultivated in various parts of the world. Both sweet and bitter kernels of apricot have been used for the treatment of different diseases such as loss of memory in Iranian traditional medicine (ITM). In the present study, the inhibitory activity of sweet and bitter extracts of apricot kernels towards cholinesterase (ChE) enzymes, both acetyl and butyrylcholinesterase was examined through Ellman's method. In addition, neuroprotectivity of aqueous extracts and amygdalin were investigated against HO-induced cell death in PC12 neurons. Among them, the best acetylcholinesterase (AChE) inhibitory activity (IC = 134.93 ± 2.88 µg/mL) and neuroprotectivity (-value < 0.0001) were obtained by the aqueous extract of bitter type. It was found that all extracts showed no butyrylcholinesterase (BChE) inhibitory activity.

Authors

  • Yasaman Vahedi-Mazdabadi
    Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Elahe Karimpour-Razkenari
    Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Tahmineh Akbarzadeh
    Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Hania Lotfian
    Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • Mohammad Toushih
    Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Neda Roshanravan
    Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Mina Saeedi
    Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • Alireza Ostadrahimi
    Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Keywords

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