Comparison of intravenous sodium bicarbonate and sodium chloride combination versus intravenous sodium chloride hydration alone in reducing amphotericin B nephrotoxicity: a randomized clinical trial.

Journal: Research in pharmaceutical sciences
Published Date: Nov 27, 2020

Abstract

BACKGROUND AND PURPOSE: The most important adverse reaction of amphotericin B (AmB) is nephrotoxicity. The aim of this study was to assess the potential effectiveness of intravenous saline + sodium bicarbonate versus intravenous sodium chloride hydration in preventing or attenuating AmB nephrotoxicity.

Authors

  • Iman Karimzadeh
    Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Science, Shiraz, I.R. Iran.
  • Asma Sepehr-Sobhani
    Department of Pharmacology-Toxicology, School of Pharmacy, Shiraz University of Medical Science, Shiraz, I.R. Iran.
  • Mohammad Javad Khoshnoud
    Department of Pharmacology-Toxicology, School of Pharmacy, Shiraz University of Medical Science, Shiraz, I.R. Iran.
  • Mohammad Mahdi Sagheb
    Nephrology-Urology Research Center and Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
  • Reza Vejdani
    Hematology Research Center and Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
  • Atefeh Jalali
    Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Science, Shiraz, I.R. Iran.
  • Motahareh Mahi-Birjand
    Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, I.R. Iran.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals