A simple and validated HPLC method for vancomycin assay in plasma samples: the necessity of TDM center development in Southern Iran.

Journal: Research in pharmaceutical sciences
Published Date: Nov 27, 2020

Abstract

BACKGROUND AND PURPOSE: Vancomycin is a glycopeptide antibiotic which is the drug of choice against methicillin-resistant . It has a narrow therapeutic index, and thus therapeutic drug monitoring (TDM), and clinical pharmacokinetic assessment are necessary in order to prevent adverse drug reactions such as nephrotoxicity. In this study, we aimed to develop a simple and validated HPLC method for vancomycin assay in order to establish a TDM center for patients admitted to the ICU of Nemazee Hospital in southern Iran.

Authors

  • Parisa Ghasemiyeh
    Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
  • Afsaneh Vazin
    Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
  • Farid Zand
    Anesthesiology and Critical Care Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
  • Amir Azadi
    Department of Pharmaceutics, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
  • Iman Karimzadeh
    Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Science, Shiraz, I.R. Iran.
  • Soliman Mohammadi-Samani
    Department of Pharmaceutics, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.

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