Regenerative rehabilitation measures to restore tissue function after arsenic exposure.

Journal: Current opinion in biomedical engineering
Published Date: Mar 11, 2024

Abstract

Environmental exposure of arsenic impairs the cardiometabolic profile, skeletal muscle health, and neurological function. Such declining tissue health is observed as early as in one's childhood, where the exposure is prevalent, thereby accelerating the effect of time's arrow. Despite the known deleterious effects of arsenic exposure, there is a paucity of specific treatment plans for restoring tissue function in exposed individuals. In this review, we propose to harness the untapped potential of existing regenerative rehabilitation programs, such as stem cell therapeutics with rehabilitation, acellular therapeutics, and artificial intelligence/robotics technologies, to address this critical gap in environmental toxicology. With regenerative rehabilitation techniques showing promise in other injury paradigms, fostering collaboration between these scientific realms offers an effective means of mitigating the detrimental effects of arsenic on tissue function.

Authors

  • Adam A Jasper
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, USA.
  • Kush H Shah
    The Lake Erie College of Osteopathic Medicine (LECOM), Erie, PA, USA.
  • Helmet Karim
    Department of Psychiatry, University of Pittsburgh, USA.
  • Swathi Gujral
    Department of Psychiatry, University of Pittsburgh, USA.
  • Iva Miljkovic
    Department of Epidemiology, University of Pittsburgh, USA.
  • Caterina Rosano
    Department of Epidemiology, University of Pittsburgh, USA.
  • Aaron Barchowsky
    Department of Environmental and Occupational Health, University of Pittsburgh, USA.
  • Amrita Sahu
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, USA.

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