Korean Red Ginseng aqueous extract improves markers of mucociliary clearance by stimulating chloride secretion.

Journal: Journal of ginseng research
Published Date: Sep 13, 2019

Abstract

BACKGROUND: Abnormal chloride (Cl) transport has a detrimental impact on mucociliary clearance in both cystic fibrosis (CF) and non-CF chronic rhinosinusitis. Ginseng is a medicinal plant noted to have anti-inflammatory and antimicrobial properties. The present study aims to assess the capability of red ginseng aqueous extract (RGAE) to promote transepithelial Cl secretion in nasal epithelium.

Authors

  • Do-Yeon Cho
    Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.
  • Daniel Skinner
    Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.
  • Shaoyan Zhang
    Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.
  • Ahmed Lazrak
    Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States.
  • Dong Jin Lim
    Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.
  • Christopher G Weeks
    Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.
  • Catherine G Banks
    Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.
  • Chang Kyun Han
    Korea Ginseng Research Institute, Korea Ginseng Corporation, Daejeon, Republic of Korea.
  • Si-Kwan Kim
    Department of Biomedical Chemistry, Konkuk University, Chungju, Republic of Korea.
  • Guillermo J Tearney
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, United States.
  • Sadis Matalon
    Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States.
  • Steven M Rowe
    Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States.
  • Bradford A Woodworth
    Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.

Keywords

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