Association of polymorphisms in , , and with post-induction infliximab trough level in Crohn's disease patients.

Journal: Gastroenterology report
Published Date: Oct 29, 2019

Abstract

BACKGROUND: Trough levels of the post-induction serum infliximab (IFX) are associated with short-term and long-term responses of Crohn's disease patients to IFX, but the inter-individual differences are large. We aimed to elucidate whether single gene polymorphisms (SNPs) within , , , , , , , and partially account for these differences and employed a multivariate regression model to predict patients' post-induction IFX levels.

Authors

  • Jian Tang
    Department of Decision Sciences HEC, Université de Montréal, Montreal, Québec, Canada.
  • Cai-Bin Zhang
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.
  • Kun-Sheng Lyu
    Southern China Center for Statistical Science School of Mathematics, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.
  • Zhong-Ming Jin
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.
  • Shao-Xing Guan
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.
  • Na You
    Southern China Center for Statistical Science School of Mathematics, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.
  • Min Huang
    Department of Physiology, School of Basic Medicine, Chengdu Medical College, Sichuan, China.
  • Xue-Ding Wang
    Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.
  • Xiang Gao
    Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.

Keywords

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