A Double-Blind, Randomized Control Trial of Rapidly Infused High Strong Ion Difference (SID) Fluid Versus Hartmann's Solution on Acid-Base Status in Sepsis Patients in the Emergency Department.

Journal: Journal of acute medicine
Published Date: Sep 1, 2019

Abstract

BACKGROUND: Balanced fluids are preferred in initial resuscitation of septic patients based on several recent studies. The Stewart's concept on acid-base balance predicts that high strong ion difference (SID) fluid thus will increase the pH level. To date, the impact of high SID fluid in septic patient with metabolic acidosis remains uncertain. We conducted single center, randomized, double-blind trial to compare the effect of high SID fluid vs. Hartmann's solution on acid-base status in selected sepsis patients in the Emergency Department.

Authors

  • Chunchiat Yeoh
    Hospital Pulau Pinang Emergency Department Pulau Pinang Malaysia.
  • Aikhowe Teo
    Hospital Pulau Pinang Emergency Department Pulau Pinang Malaysia.
  • Abdul Muhaimin Noor Azhar
    University of Malaya Emergency Department Wilayah Persekutuan Kuala Lumpur Malaysia.
  • Sherene Tan Suann
    Hospital Pulau Pinang Pharmacy Department Pulau Pinang Malaysia.
  • Yingying Thum
    Hospital Pulau Pinang Emergency Department Pulau Pinang Malaysia.
  • Kwanhathai Darin Wong
    Hospital Pulau Pinang Emergency Department Pulau Pinang Malaysia.
  • Huahchiang Ooi
    Hospital Pulau Pinang Emergency Department Pulau Pinang Malaysia.
  • Sasi Kumar A/L Sappanie
    Hospital Pulau Pinang Emergency Department Pulau Pinang Malaysia.
  • Aidawati Bustam
    University of Malaya Emergency Department Wilayah Persekutuan Kuala Lumpur Malaysia.
  • Rashidi Ahmad
    University of Malaya Emergency Department Wilayah Persekutuan Kuala Lumpur Malaysia.

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