Simple water-based tacrolimus enemas for refractory proctitis.
Journal:
JGH open : an open access journal of gastroenterology and hepatology
Published Date:
Nov 14, 2019
Abstract
BACKGROUND AND AIMS: Rectal ulcerative colitis (UC) and Crohn's disease (CD) often do not respond to conventional therapies. Oral and suppository tacrolimus are effective but often poorly tolerated or are complex to formulate. Tacrolimus is topically active, water soluble, and has minimal systemic toxicity when administered rectally; we therefore tested a simple tap water-based enema formulation.
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