Validation of a simple equation for glomerular filtration rate measurement based on plasma iohexol disappearance.

Journal: Clinical kidney journal
Published Date: Jul 23, 2019

Abstract

BACKGROUND: A simple equation for glomerular filtration rate (GFR) measurement based on only plasma samples during the slow compartment after injection of iohexol was previously developed among children with chronic kidney disease and adult men with or at risk of HIV infection [Chronic Kidney Disease in Children (CKiD)-Multicenter AIDS Cohort Study (MACS) equation], but has not been externally validated. We aimed to evaluate the performance of the CKiD-MACS equation among elderly participants in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort who underwent directly measured iohexol GFR.

Authors

  • Derek K Ng
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Andrew S Levey
    Division of Nephrology, Tufts Medical Center, Boston, MA, USA.
  • Michael G Shlipak
    Kidney Health Research Collaborative, San Francisco VA Medical Center, University of California, San Francisco, CA, USA.
  • Alvaro Muñoz
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Lesley A Inker
    Division of Nephrology, Tufts Medical Center, Boston, MA, USA.
  • Tariq Shafi
    Division of Nephrology, The University of Mississippi Medical Center, Jackson, MS, USA.

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