Palonosetron Pretreatment is not as Effective as Lignocaine for Attenuation of Pain on Injection of Propofol.

Journal: Turkish journal of anaesthesiology and reanimation
Published Date: Oct 4, 2019

Abstract

OBJECTIVE: 5-HT3 receptor antagonists are known to possess local anesthetic properties and are commonly used for the alleviation of pain following propofol injection. Palonosetron, a newer molecule, has shown contradictory results for this property. The aim of this study was to compare the effect of palonosetron pretreatment in alleviating propofol injection pain with that of lignocaine. Their comparative effect on various hemodynamic parameters was also evaluated.

Authors

  • Ravi Kant
    Medical Biotechnology Laboratory, Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi, India.
  • Prakash K Dubey
    Indira Gandhi Institute of Medical Sciences, Patna, India.
  • Alok Ranjan
    All India Institute of Medical Sciences, Patna, India.

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