Hepatitis B surface antigen reduction as a result of switching from long-term entecavir administration to tenofovir.

Journal: JGH open : an open access journal of gastroenterology and hepatology
Published Date: Oct 24, 2019

Abstract

BACKGROUND AND AIM: Loss of hepatitis B surface antigen (HBsAg) is an important goal in the treatment of chronic hepatitis B. We investigated whether switching from long-term entecavir (ETV) administration to tenofovir (TFV) (tenofovir alafenamide [TAF] or tenofovir disoproxil fumarate [TDF]) could contribute to the reduction of HBsAg levels.

Authors

  • Nobuharu Tamaki
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Masayuki Kurosaki
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Sakura Kirino
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Koji Yamashita
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Leona Osawa
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Shuhei Sekiguchi
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Yuka Hayakawa
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Wan Wang
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Mao Okada
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Mayu Higuchi
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Kenta Takaura
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Chiaki Maeyashiki
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Shun Kaneko
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Yutaka Yasui
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Kaoru Tsuchiya
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Hiroyuki Nakanishi
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Jun Itakura
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Yuka Takahashi
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.
  • Nobuyuki Enomoto
    First Department of Internal Medicine, Faculty of Medicine University of Yamanashi Kofu Japan.
  • Namiki Izumi
    Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Tokyo Japan.

Keywords

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