An experimental framework for conjoint measures of olfaction, navigation, and motion as pre-clinical biomarkers of Alzheimer's disease.

Journal: Journal of Alzheimer's disease reports
Published Date: Dec 23, 2024

Abstract

Elucidating Alzheimer's disease (AD) prodromal symptoms can resolve the outstanding challenge of early diagnosis. Based on intrinsically related substrates of olfaction and spatial navigation, we propose a novel experimental framework for their conjoint study. Artificial intelligence-driven multimodal study combining self-collected olfactory and motion data with available big clinical datasets can potentially promote high-precision early clinical screenings to facilitate timely interventions targeting neurodegenerative progression.

Authors

  • Katarina Biljman
    Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China.
  • Illana Gozes
    Elton Laboratory for Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Faculty of Medical and Health Sciences, The Adams Super Center for Brain Studies and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
  • Jacqueline Ck Lam
    Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China.
  • Victor Ok Li
    Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China.

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