Trans-Differentiation of Human Dental Pulp Stem Cells Into Cholinergic-Like Neurons Via Nerve Growth Factor.

Journal: Basic and clinical neuroscience
Published Date: Nov 1, 2019

Abstract

INTRODUCTION: Cell therapy has been widely considered as a therapeutic approach for neurodegenerative diseases and nervous system damage. Cholinergic neurons as one of the most important neurons that play a significant role in controlling emotions, mobility, and autonomic systems. In this study, Human Dental Pulp Stem Cells (hDPSCs) were differentiated into the cholinergic neurons by β-mercaptoethanol in the preinduction phase and also by the nerve growth factor (NGF) in the induction phase.

Authors

  • Shahram Darabi
    Cellular and Molecular Research Center, Qazvin University of Medical Science, Qazvin, Iran.
  • Taki Tiraihi
    Department of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Tehran.
  • Maryam Nazm Bojnordi
    Department of Anatomy & Cell Biology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
  • Hatef Ghasemi Hamidabadi
    Department of Anatomy & Cell Biology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
  • Nourollah Rezaei
    Department of Anatomy & Cell Biology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
  • Maria Zahiri
    The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
  • Rafieh Alizadeh
    ENT and Head & Neck Research Center and Department, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

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