Computational Prediction of Ubiquitination Proteins Using Evolutionary Profiles and Functional Domain Annotation.

Journal: Current genomics
Published Date: Aug 1, 2019

Abstract

BACKGROUND: Ubiquitination, as a post-translational modification, is a crucial biological process in cell signaling, apoptosis, and localization. Identification of ubiquitination proteins is of fundamental importance for understanding the molecular mechanisms in biological systems and diseases. Although high-throughput experimental studies using mass spectrometry have identified many ubiquitination proteins and ubiquitination sites, the vast majority of ubiquitination proteins remain undiscovered, even in well-studied model organisms.

Authors

  • Wangren Qiu
    Computer Department, Jingdezhen Ceramic Institute, Jingdezhen 333046, China.
  • Chunhui Xu
    Informatics Institute, University of Missouri, Columbia, MO 65201, USA.
  • Xuan Xiao
    Computer Department, Jingdezhen Ceramic Institute, Jingdezhen 333046, China.
  • Dong Xu
    Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO, USA.

Keywords

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