The First Report on Pharmacokinetic/Pharmacodynamic Study of Trimethoprim/Sulfamethoxazole against Staphylococcus aureus with a Neutropenic Murine Thigh Infection Model.

Journal: Chemotherapy
Published Date: May 20, 2020

Abstract

INTRODUCTION: With an increase in the incidence of Staphylococcus aureus infections in the healthcare settings and in the community, trimethoprim/sulfamethoxazole (TMP/SMX) has been suggested as a convenient treatment option. However, the appropriate dosage regimen of TMP/SMX is unclear.

Authors

  • Mao Hagihara
    Department of Molecular Epidemiology and Biomedical Sciences, Aichi Medical University, Aichi, Japan.
  • Hideo Kato
    Department of Clinical Infectious Diseases, Aichi Medical University, Aichi, Japan.
  • Shinya Uchida
    Department of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
  • Rieko Yamashita
    Department of Molecular Epidemiology and Biomedical Sciences, Aichi Medical University, Aichi, Japan.
  • Shimako Tanaka
    Department of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
  • Daisuke Sakanashi
    Department of Clinical Infectious Diseases, Aichi Medical University, Aichi, Japan.
  • Arufumi Shiota
    Department of Clinical Infectious Diseases, Aichi Medical University, Aichi, Japan.
  • Nobuhiro Asai
    Department of Clinical Infectious Diseases, Aichi Medical University, Aichi, Japan.
  • Yusuke Koizumi
    Department of Clinical Infectious Diseases, Aichi Medical University, Aichi, Japan.
  • Hiroyuki Suematsu
    Department of Clinical Infectious Diseases, Aichi Medical University, Aichi, Japan.
  • Yuka Yamagishi
    Department of Clinical Infectious Diseases, Aichi Medical University, Aichi, Japan.
  • Noriyuki Namiki
    Department of Pharmacy Practice and Science, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
  • Hiroshige Mikamo
    Department of Clinical Infectious Diseases, Aichi Medical University, Aichi, Japan, mikamo@aichi-med-u.ac.jp.

Keywords

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