A new M23-based ELISA assay for anti-aquaporin 4 autoantibodies: diagnostic accuracy and clinical correlation.

Journal: Auto- immunity highlights
Published Date: Jun 19, 2019

Abstract

PURPOSE: Although many assays have been developed to detect anti-aquaporin-4 (AQP4) antibodies, most of these assays require sophisticated techniques and are thus only available at specialized laboratories. The aim of this study was to evaluate the analytical and clinical performance of a new commercial enzyme-linked immunosorbent assay (ELISA RSR, AQP4 Ab Version 2) to detect anti-AQP4 antibodies performed on a fully automated system (SkyLAB 752).

Authors

  • Marilina Tampoia
    1Clinical Pathology Laboratory, Polyclinic of Bari, Department of Biomedical Sciences and Human Oncology, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy.
  • Letizia Abbracciavento
    1Clinical Pathology Laboratory, Polyclinic of Bari, Department of Biomedical Sciences and Human Oncology, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy.
  • Giuseppina Barberio
    2Laboratory Medicine, Department of Clinical Pathology, Treviso Hospital, Treviso, Italy.
  • Martina Fabris
    3Laboratory of Immunopathology and Allergology, University Hospital Udine, P.le S. Maria della Misericordia 15, 33100 Udine, Italy.
  • Nicola Bizzaro
    4Laboratory of Clinical Pathology, San Antonio Hospital, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy.

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