Effect of lipopolysaccharide on cell proliferation and vascular endothelial growth factor secretion of periodontal ligament stem cells.

Journal: The Saudi dental journal
Published Date: Aug 23, 2019

Abstract

PURPOSE: Periodontal ligament stem cells (PDLSCs) have considerable potential for use as a means of achieving periodontal regeneration due to their noteworthy proliferative properties and secretory functions. In particular, PDLSCs secrete vascular endothelial growth factor (VEGF) which enhances angiogenesis and osteogenesis. The resulting repair and development of blood vessels and hard tissues which would occur in the presence of these cells could be central to an effective periodontal regeneration procedure.The bacterial biofilm of tooth surface related to the periodontium might provide either an inhibition or a stimulus to different factors involved in a regenerative process. Cell culture experiments have been investigated by adding lipopolysaccharide (LPS) to the culture medium but the effect of various concentration of LPS in these circumstances has not been investigated. Therefore, this study aimed to investigate the effect of LPS concentrations on proliferation of PDLSCs and on their secretion of VEGF.

Authors

  • Jia Yee Keong
    School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.
  • Li Wei Low
    School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.
  • Jean Mun Chong
    School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.
  • Yan Yi Ong
    School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.
  • Shaju Jacob Pulikkotil
    Department of Periodontology and Implantology, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.
  • Gurbind Singh
    School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia.
  • Venkateshbabu Nagendrababu
    Department of Endodontics, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.
  • Spoorthi Ravi Banavar
    Department of Oral Medicine and Pathology, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.
  • Suan Phaik Khoo
    Department of Oral Medicine and Pathology, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.

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