The greater inflammatory pathway-high clinical potential by innovative predictive, preventive, and personalized medical approach.

Journal: The EPMA journal
Published Date: Dec 10, 2019

Abstract

BACKGROUND AND LIMITATIONS: Impaired wound healing (WH) and chronic inflammation are hallmarks of non-communicable diseases (NCDs). However, despite WH being a recognized player in NCDs, mainstream therapies focus on (un)targeted damping of the inflammatory response, leaving WH largely unaddressed, owing to three main factors. The first is the complexity of the pathway that links inflammation and wound healing; the second is the dual nature, local and systemic, of WH; and the third is the limited acknowledgement of genetic and contingent causes that disrupt physiologic progression of WH.

Authors

  • Maria Giovanna Maturo
    1Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
  • Marzia Soligo
    2Institute of Translational Pharmacology, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy.
  • Greg Gibson
    3Center for Integrative Genomics, School of Biological Sciences, Georgia Tech, Atlanta, GA USA.
  • Luigi Manni
    2Institute of Translational Pharmacology, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy.
  • Christine Nardini
    4IAC Institute for Applied Computing, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy.

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