L-arginase induces vascular dysfunction in old spontaneously hypertensive rats.

Journal: Journal of African Association of Physiological Sciences
Published Date: Dec 1, 2019

Abstract

BACKGROUND: Aging is a major non-modifiable risk factor for hypertension. Changes in aging are similar to those seen in hypertension in the vasculature. Also, aging increases the vascular dysfunction that occurs in hypertension. L-arginase action reduces substrate (L-arginine) availability for the formation of nitric oxide (NO). This reduces the level of NO and leads to reduced vasodilation and ultimately, vascular dysfunction. This study examines the hypothesis that age-dependent vascular dysfunction in SHRs is mediated by arginase.

Authors

  • O Arishe
    Department of Physiology, Medical College of Georgia at Augusta University, Augusta, GA, USA.
  • J McKenzie
    Department of Physiology, Medical College of Georgia at Augusta University, Augusta, GA, USA.
  • F Priviero
    Department of Physiology, Medical College of Georgia at Augusta University, Augusta, GA, USA.
  • A B Ebeigbe
    Department of Physiology College of Medical Sciences, University of Benin, Benin City, Nigeria.
  • R Clinton Webb
    Department of Physiology, Medical College of Georgia at Augusta University, Augusta, GA, USA.

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