Improve hot region prediction by analyzing different machine learning algorithms.
Journal:
BMC bioinformatics
Published Date:
Oct 25, 2021
Abstract
BACKGROUND: In the process of designing drugs and proteins, it is crucial to recognize hot regions in protein-protein interactions. Each hot region of protein-protein interaction is composed of at least three hot spots, which play an important role in binding. However, it takes time and labor force to identify hot spots through biological experiments. If predictive models based on machine learning methods can be trained, the drug design process can be effectively accelerated.