Effects of dichloromethane spp. extract on the lipopolysaccharide-induced expression of nuclear factor-kappa B and inducible nitric oxide synthase in mice.

Journal: Veterinary world
Published Date: Dec 3, 2019

Abstract

BACKGROUND AND AIM: The soft coral genus is a source of cembraneterpen. is reported to have anti-inflammatory properties, with the ability to reduce the expression of inducible nitric oxide synthase (iNOS) and inhibit nuclear factor-kappa B (NF-κB) activation. This study aimed to investigate the efficacy of dichloromethane (DCM) extracts of soft coral spp. to inhibit the expression of NF-κB and iNOS induced by lipopolysaccharide (LPS).

Authors

  • Putut Har Riyadi
    Postgraduate Program, Faculty of Fisheries and Marine Science, Brawijaya University, Malang 65145, East Java, Indonesia.
  • Didik Wahyudi
    Department of Biology, Faculty of Science and Technology, State Islamic University of Maulana Malik Ibrahim Malang, Malang 65144, East Java, Indonesia.
  • Wendy Alexander Tanod
    Department of Fisheries Product Technology, Institute of Fisheries and Marine (Sekolah Tinggi Perikanan dan Kelautan), Palu 94118, Central Sulawesi, Indonesia.

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