Insulin Resistance Associated with Plasma Xanthine Oxidoreductase Activity Independent of Visceral Adiposity and Adiponectin Level: MedCity21 Health Examination Registry.

Journal: International journal of endocrinology
Published Date: Dec 30, 2019

Abstract

BACKGROUND: Higher levels of uric acid production have been reported in individuals with visceral fat obesity, and obesity is known to enhance xanthine oxidoreductase (XOR) activity, although the precise mechanism remains unclear. We investigated the associations of visceral fat area (VFA), serum adiponectin level, and insulin resistance with plasma XOR activity using our novel highly sensitive assay based on [C,N] xanthine and liquid chromatography/triple quadrupole mass spectrometry.

Authors

  • Masafumi Kurajoh
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Shinya Fukumoto
    Department of Premier Preventive Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Takayo Murase
    Mie Research Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd., Inabe, Mie, Japan.
  • Takashi Nakamura
    Mie Research Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd., Inabe, Mie, Japan.
  • Takuma Ishihara
    Innovative and Clinical Research Promotion Center, Gifu University Hospital, Gifu, Japan.
  • Hirofumi Go
    Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Kouji Yamamoto
    Department of Biostatistics, School of Medicine, Yokohama City University, Yokohama, Japan.
  • Shinya Nakatani
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Akihiro Tsuda
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Tomoaki Morioka
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Katsuhito Mori
    Department of Nephrology, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Yasuo Imanishi
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Masaaki Inaba
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Masanori Emoto
    Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.

Keywords

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