CusS-CusR Two-Component System Mediates Tigecycline Resistance in Carbapenem-Resistant .

Journal: Frontiers in microbiology
Published Date: Jan 28, 2020

Abstract

BACKGROUND: The increase in carbapenem-resistant (CRKP), especially the emergence of tigecycline-resistant (KP), is a serious public health concern. However, the underlying mechanism of tigecycline resistance is unclear. In this study, we evaluated the role of the CusS-CusR two-component system (TCS), which is associated with copper/silver resistance, in tigecycline resistance in CRKP.

Authors

  • Dongjie Chen
    Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
  • Yunan Zhao
    Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
  • Yanqin Qiu
    Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
  • Liying Xiao
    Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
  • Huaqiang He
    Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
  • Dongmei Zheng
    Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
  • Xiaoqin Li
    Department of Pulmonary and Critical Care Medicine, Fujian Provincial Hospital, Fuzhou, China.
  • Xiaoli Yu
    Hangzhou Institute of Innovative Medicine, Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China.
  • Nengluan Xu
    Department of Pulmonary and Critical Care Medicine, Fujian Provincial Hospital, Fuzhou, China.
  • Xinlan Hu
    Clinical Microbiology Laboratory, Fujian Provincial Hospital, Fuzhou, China.
  • Falin Chen
    Clinical Microbiology Laboratory, Fujian Provincial Hospital, Fuzhou, China.
  • Hongru Li
    Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
  • Yusheng Chen
    Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.

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