Minding the gaps: The importance of navigating holes in protein fitness landscapes.
Journal:
Cell systems
Published Date:
Nov 17, 2021
Abstract
Machine-learning-guided protein design is rapidly emerging as a strategy to find high-fitness multi-mutant variants. In this issue of Cell Systems, Wittman et al. analyze the impact of design decisions for machine-learning-assisted directed evolution (MLDE) on its ability to navigate a fitness landscape and reliably find global optima.