Evaluation of platelet-rich plasma from diabetic donors shows increased platelet vascular endothelial growth factor release.

Journal: Stem cell investigation
Published Date: Dec 20, 2019

Abstract

BACKGROUND: Platelet-rich plasma (PRP) contains pro-angiogenic growth factors including vascular endothelial growth factor (VEGF). Angiogenesis is a necessary component of wound healing in instances of diabetic foot ulcers (DFU). PRP composition varies depending on methods and donor health status. Our group has developed an improved PRP protocol for diabetes treatment. The aims of this study were to examine the levels of the pro-angiogenic factor VEGF in these patient populations with and without diabetes.

Authors

  • Karina
    Doctoral Program of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
  • Komang Ardi Wahyuningsih
    Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia.
  • Siti Sobariah
    Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia.
  • Iis Rosliana
    Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia.
  • Imam Rosadi
    Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia.
  • Tias Widyastuti
    Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia.
  • Irsyah Afini
    Hayandra Lab, Yayasan Hayandra Peduli, Jakarta, Indonesia.
  • Septelia Inawati Wanandi
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
  • Pradana Soewondo
    Division of Metabolism and Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
  • Heri Wibowo
    Laboratorium Terpadu, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
  • Jeanne Adiwinata Pawitan
    Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Keywords

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