Relationship of soluble ST2 to pulmonary hypertension severity in patients undergoing cardiac resynchronization therapy.

Journal: Journal of thoracic disease
Published Date: Dec 1, 2019

Abstract

BACKGROUND: Pulmonary hypertension (PH) is an adverse prognostic marker in patients undergoing cardiac resynchronization therapy (CRT). We sought to determine the relation of biomarkers of fibrosis [soluble ST2 (sST2), galectin-3], wall stretch [amino terminal pro-brain natriuretic peptide (NT-proBNP)], and necrosis [high-sensitivity troponin-I (hsTnI)] to PH severity in CRT patients.

Authors

  • Jonathan Beaudoin
    Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Québec City, QC, Canada.
  • Jackie Szymonifka
    Department of Biostatistics, New York University, New York, NY, USA.
  • Zachary Lavender
    Division of Medicine, Hartford Hospital, Hartford, CT, USA.
  • Roderick C Deaño
    Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
  • Qing Zhou
    Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • James L Januzzi
    Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Jagmeet P Singh
    Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Quynh A Truong
    Department of Biostatistics, New York University, New York, NY, USA.

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